Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor microenvironment. Consequently, SPHK1‐packaged...

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Bibliographic Details
Published in:	Advanced science 2022-05, Vol.9 (14), p.e2104452-n/a
Main Authors:	Gupta, Prachi, Kadamberi, Ishaque Pulikkal, Mittal, Sonam, Tsaih, Shirng‐Wern, George, Jasmine, Kumar, Sudhir, Vijayan, Dileep K., Geethadevi, Anjali, Parashar, Deepak, Topchyan, Paytsar, McAlarnen, Lindsey, Volkman, Brian F, Cui, Weiguo, Zhang, Kam Y. J., Di Vizio, Dolores, Chaluvally‐Raghavan, Pradeep, Pradeep, Sunila
Format:	Article
Language:	English
Subjects:	Angiogenesis Antibodies Apoptosis Biosynthesis Cancer therapies Carcinoma, Ovarian Epithelial Extracellular vesicles Extracellular Vesicles - metabolism Female Humans Immunotherapy Kinases Lymphocytes Melanoma Metastasis Microscopy Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Plasma Proteins Receptors, Lysosphingolipid - metabolism Receptors, Lysosphingolipid - therapeutic use S1P Sphingosine - metabolism Sphingosine - therapeutic use SPHK1 T cell exhaustion T-Lymphocytes - metabolism T-Lymphocytes - pathology Tumor Microenvironment Variance analysis
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