Review article: Lynch Syndrome—a mechanistic and clinical management update

Summary Background Lynch syndrome (LS) is an autosomal dominant familial condition caused by a pathogenic variant (PV) in a DNA mismatch repair gene, which then predisposes carriers to various cancers. Aim To review the pathogenesis, clinical presentation, differential diagnosis and clinical strateg...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2022-04, Vol.55 (8), p.960-977
Main Authors: Curtius, Kit, Gupta, Samir, Boland, C. Richard
Format: Article
Language:English
Subjects:
Cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Colorectal Neoplasms, Hereditary Nonpolyposis - therapy
Differential diagnosis
DNA Mismatch Repair - genetics
DNA repair
Endometrium
Genetic screening
Genetic Testing - methods
Humans
Immunogenicity
Management
Microsatellite Instability
Mismatch repair
Pathogenesis
Reviews
Tumors
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