PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer

Cancer cells are dependent on protein quality‐control mechanisms, including protein chaperones, the ubiquitin‐proteasome system, and autophagy. The p62 receptor is a classical, ubiquitously expressed receptor, involved in many signal transduction pathways. Upregulation and/or reduced degradation of...

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Bibliographic Details
Published in:Chemical biology & drug design 2022-11, Vol.100 (5), p.623-638
Main Authors: Kalid, Ori, Gotliv, Irina, Levy‐Apter, Einat, Beker, Danit Finkelshtein, Cherniavsky‐Lev, Marina, Rotem, Etai, Miron, Naama
Format: Article
Language:English
Subjects:
animal model of cancer
cell surface receptor drug target
in vitro model of cancer
receptors
xenograft model
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