Adenocarcinoma in situ or early-stage cervical cancer is a risk factor for preterm delivery after cervical conization: a multicenter observational study

Pregnancy after conization is associated with a high risk of preterm delivery. However, because risk factors for preterm delivery after conization remain unknown, we conducted a multicenter observational study to investigate risk factors associated with preterm delivery. We selected patients who had...

Full description

Saved in:
Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2022-12, Vol.35 (25), p.9837-9842
Main Authors: Kasuga, Yoshifumi, Ikenoue, Satoru, Nishio, Hiroshi, Yamagami, Wataru, Ochiai, Daigo, Tanabe, Kiyoo, Tashima, Yasuhiro, Hirao, Nobumaru, Miyakoshi, Kei, Kasai, Kenji, Suda, Yoshio, Nemoto, Taiko, Shiraishi, Satoru, Yoshida, Hiroyuki, Kurahashi, Takashi, Takamatsu, Kiyoshi, Iwasaki, Shinya, Yamashita, Hiroshi, Akiba, Yasuo, Arase, Toru, Hara, Sumiko, Nakada, Sakura, Tanaka, Mamoru, Aoki, Daisuke
Format: Article
Language:English
Subjects:
cervical cancer
Conization
pregnancy
preterm delivery
ultrasound
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pregnancy after conization is associated with a high risk of preterm delivery. However, because risk factors for preterm delivery after conization remain unknown, we conducted a multicenter observational study to investigate risk factors associated with preterm delivery. We selected patients who had previously undergone conization and reviewed medical records from 18 hospitals in cooperation with Keio University School of Medicine between January 2013 and December 2019. Women were classified as nulliparous and primiparous, and a multiple logistic regression analysis was performed to evaluate the relative contributions of the various maternal risk factors for preterm delivery (i.e. delivery before 37 gestational weeks). Among 409 pregnant women after conization, 68 women delivered preterm (17%). The incidence of nulliparity (p = .014) was higher and a history of preterm delivery (p = .0010) was more common in the preterm delivery group than in the term delivery group. Furthermore, the proportion of women diagnosed with adenocarcinoma in situ (AIS) and cervical cancer in the preterm delivery group was higher than that in the term delivery group (p = .0099 and .0004, respectively). In multiple regression models in nulliparous women, cervical cancer or AIS (Odds ratio [OR]: 4.16, 95% CI: 1.26-13.68, p = .019) and a short cervix in the second trimester (OR: 13.41, 95% CI: 3.88-46.42, p 
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2022.2056835