Age-dependent formation of TMEM106B amyloid filaments in human brains

Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and transactive response DNA-binding protein (TARDBP; also known as TDP-43) are the mo...

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Published in:	Nature (London) 2022-05, Vol.605 (7909), p.310-314
Main Authors:	Schweighauser, Manuel, Arseni, Diana, Bacioglu, Mehtap, Huang, Melissa, Lövestam, Sofia, Shi, Yang, Yang, Yang, Zhang, Wenjuan, Kotecha, Abhay, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Newell, Kathy L., Tarutani, Airi, Murayama, Shigeo, Miyazaki, Masayuki, Saito, Yuko, Yoshida, Mari, Hasegawa, Kazuko, Lashley, Tammaryn, Revesz, Tamas, Kovacs, Gabor G., van Swieten, John, Takao, Masaki, Hasegawa, Masato, Ghetti, Bernardino, Spillantini, Maria Grazia, Ryskeldi-Falcon, Benjamin, Murzin, Alexey G., Goedert, Michel, Scheres, Sjors H. W.
Format:	Article
Language:	English
Subjects:	101/28 13/51 631/378/340 631/535/1258/1259 Age Aging Alzheimer's disease Amyloid - metabolism Amyloid beta-Peptides - metabolism Amyloidosis - metabolism Antibodies Brain Brain - metabolism Cortex (frontal) Dementia DNA-binding protein Electron microscopy Filaments Humanities and Social Sciences Humans Inclusion bodies Inclusions Membrane Proteins - metabolism Microscopy Movement disorders multidisciplinary Nerve Tissue Proteins - metabolism Neurodegenerative diseases Neurology Packaging Parkinson's disease Plaque, Amyloid - metabolism Proteins Science Science (multidisciplinary) Synuclein Tau protein tau Proteins - metabolism Tauopathies - metabolism
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