Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear. We performed muscle biopsies in 15 octogenarian world-class track and field MAs and 14 non-athlete age/sex-matched...

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Bibliographic Details
Published in:	eLife 2022-04, Vol.11
Main Authors:	Ubaida-Mohien, Ceereena, Spendiff, Sally, Lyashkov, Alexey, Moaddel, Ruin, MacMillan, Norah J, Filion, Marie-Eve, Morais, Jose A, Taivassalo, Tanja, Ferrucci, Luigi, Hepple, Russell T
Format:	Article
Language:	English
Subjects:	Age groups Aged, 80 and over Aging Antibodies Athletes Biopsy Canada Copy number Cristae DNA Copy Number Variations DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Electron transport Epidemiology and Global Health Exercise Frailty Humans Mass spectroscopy Membrane proteins mitochondria Mitochondria - metabolism Mitochondrial DNA Muscle, Skeletal - metabolism Musculoskeletal system Octogenarians Peptides Physical activity Physical fitness Proteins Proteomics Quadriceps Muscle Search engines skeletal muscle Structure-function relationships Track & field
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