Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations perfor...

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Bibliographic Details
Published in:RSC advances 2018-04, Vol.8 (23), p.12614-12618
Main Authors: Du, Li-Hua, Shen, Jia-Hong, Dong, Zhen, Zhou, Na-Ni, Cheng, Bing-Zhuo, Ou, Zhi-Min, Luo, Xi-Ping
Format: Article
Language:English
Subjects:
Acylation
Antiretroviral drugs
Chemistry
Continuous flow
Esters
Hydroxyl groups
Lipase
Microreactors
Regioselectivity
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Summary:We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations. We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra01030g