Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations perfor...

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Published in:RSC advances 2018-04, Vol.8 (23), p.12614-12618
Main Authors: Du, Li-Hua, Shen, Jia-Hong, Dong, Zhen, Zhou, Na-Ni, Cheng, Bing-Zhuo, Ou, Zhi-Min, Luo, Xi-Ping
Format: Article
Language:English
Subjects:
Acylation
Antiretroviral drugs
Chemistry
Continuous flow
Esters
Hydroxyl groups
Lipase
Microreactors
Regioselectivity
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cited_by cdi_FETCH-LOGICAL-c428t-5c2871142416732fbca9cb5816127e64a94b2eb6ff3431cb8455258529a80e243
cites cdi_FETCH-LOGICAL-c428t-5c2871142416732fbca9cb5816127e64a94b2eb6ff3431cb8455258529a80e243
container_end_page 12618
container_issue 23
container_start_page 12614
container_title RSC advances
container_volume 8
creator Du, Li-Hua
Shen, Jia-Hong
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Luo, Xi-Ping
description We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations. We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.
doi_str_mv 10.1039/c8ra01030g
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subjects Acylation
Antiretroviral drugs
Chemistry
Continuous flow
Esters
Hydroxyl groups
Lipase
Microreactors
Regioselectivity
title Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
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