Integrative analysis of clinical and epigenetic biomarkers of mortality

DNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome‐wide association study of whole blood DNAm in relation to mortality i...

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Bibliographic Details
Published in:Aging cell 2022-06, Vol.21 (6), p.e13608-n/a
Main Authors: Huan, Tianxiao, Nguyen, Steve, Colicino, Elena, Ochoa‐Rosales, Carolina, Hill, W. David, Brody, Jennifer A., Soerensen, Mette, Zhang, Yan, Baldassari, Antoine, Elhadad, Mohamed Ahmed, Toshiko, Tanaka, Zheng, Yinan, Domingo‐Relloso, Arce, Lee, Dong Heon, Ma, Jiantao, Yao, Chen, Liu, Chunyu, Hwang, Shih‐Jen, Joehanes, Roby, Fornage, Myriam, Bressler, Jan, Meurs, Joyce B.J., Debrabant, Birgit, Mengel‐From, Jonas, Hjelmborg, Jacob, Christensen, Kaare, Vokonas, Pantel, Schwartz, Joel, Gahrib, Sina A., Sotoodehnia, Nona, Sitlani, Colleen M., Kunze, Sonja, Gieger, Christian, Peters, Annette, Waldenberger, Melanie, Deary, Ian J., Ferrucci, Luigi, Qu, Yishu, Greenland, Philip, Lloyd‐Jones, Donald M., Hou, Lifang, Bandinelli, Stefania, Voortman, Trudy, Hermann, Brenner, Baccarelli, Andrea, Whitsel, Eric, Pankow, James S., Levy, Daniel
Format: Article
Language:English
Subjects:
Age
Biomarkers
Blood
cancer
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Death
Diabetes
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic
Epigenetics
Epigenomics
Gene expression
Genomes
Heart
Humans
Hypertension
KCNQ4 protein
Longevity
machine learning
Male
Meta-analysis
Mortality
Neoplasms - genetics
Potassium channels (voltage-gated)
Prediction models
Prostate cancer
Risk factors
Sensitivity analysis
Skin cancer
Womens health
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