High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway

Diabetes is a risk factor for Alzheimer’s disease (AD), which is also called type 3 diabetes with insulin reduction and insulin resistance in AD patient brains. However, the molecular mechanism coupling diabetes to AD onset remains incompletely understood. Here we show that inflammation, associated...

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Bibliographic Details
Published in:	Molecular psychiatry 2022-08, Vol.27 (8), p.3396-3409
Main Authors:	Liu, Pai, Wang, Zhi-Hao, Kang, Seong Su, Liu, Xia, Xia, Yiyuan, Chan, Chi-Bun, Ye, Keqiang
Format:	Article
Language:	English
Subjects:	14/34 631/378 692/699 82/1 82/80 96/35 96/63 Alzheimer Disease - metabolism Alzheimer's disease Animals Anti-inflammatory agents Aspirin Behavioral Sciences Biological Psychology Brain - metabolism CCAAT-Enhancer-Binding Protein-beta - metabolism Cognitive ability Diabetes Diabetes mellitus Diabetes Mellitus - metabolism Diet, High-Fat - adverse effects Disease Models, Animal High fat diet Inflammation Inflammation - metabolism Insulin Insulin resistance Insulin Resistance - physiology Lipopolysaccharides Medicine Medicine & Public Health Mice Mice, Transgenic Neurodegenerative diseases Neurosciences Pharmacotherapy Psychiatry Risk factors Tau protein Transgenic mice
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