Research Progress in High-Sugar Diet and Inflammatory Diseases

High-sugar diet causes various diseases, including insulin resistance, diabetes, and non-alcoholic fatty liver disease (NAFLD). In recent years, as researchers probe deeper and deeper into issues concerning high-sugar diet, the impact of high-sugar diet on inflammatory diseases such as autoimmune di...

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Bibliographic Details
Published in:Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban 2022-05, Vol.53 (3), p.538
Main Authors: Zhang, Wei, Ma, Xiao, Cheng, Hao, Zhang, Dun-Fang
Format: Article
Language:Chinese
Subjects:
Autoimmune Diseases - complications
Diet - adverse effects
Fructose - adverse effects
Glucose
Humans
Non-alcoholic Fatty Liver Disease - etiology
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Summary:High-sugar diet causes various diseases, including insulin resistance, diabetes, and non-alcoholic fatty liver disease (NAFLD). In recent years, as researchers probe deeper and deeper into issues concerning high-sugar diet, the impact of high-sugar diet on inflammatory diseases such as autoimmune diseases and infectious diseases has been gradually uncovered and clarified. In this review, we summarized the current research progress on high-sugar diet and inflammatory diseases, and suggested that a high-sugar diet based on high intake of glucose and fructose may be an important factor inducing the exacerbation of chronic inflammatory diseases such as autoimmune diseases. Moreover, we also summarized the regulatory mechanisms through which high-sugar diet induces exacerbation of inflammatory diseases. In addition, we stated that conducting extensive clinical research and research in real-life settings and pursuing thorough investigation to reveal the different involvement of high-glucose diet and high-fructose d
ISSN:1672-173X
DOI:10.12182/20220560103