Mice with Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma via overactivation of YAP signaling

Chondrosarcoma (CHS) is a rare type of soft sarcoma with increased production of cartilage matrix arising from soft bone tissues. Currently, surgical resection is the primary clinical treatment for chondrosarcoma due to the poor response to radiotherapy and chemotherapy. However, the therapeutic eff...

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Bibliographic Details
Published in:Cell death & disease 2022-06, Vol.13 (6), p.570-11, Article 570
Main Authors: Li, Yang, Yang, Shuting, Liu, Yang, Yang, Shuying
Format: Article
Language:English
Subjects:
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Animal models
Animals
Antibodies
Biochemistry
Biomedical and Life Sciences
Bone matrix
Bone Neoplasms - pathology
Bone tumors
Cartilage
Cell Biology
Cell Culture
Cell migration
Cell proliferation
Chemotherapy
Chondrocytes
Chondrocytes - metabolism
Chondrosarcoma
Chondrosarcoma - metabolism
Immunology
Life Sciences
Lung cancer
Lung Neoplasms - pathology
Metastases
Metastasis
Metformin
Mice
Radiation therapy
Retinoblastoma
Sarcoma
Signal Transduction - genetics
Yes-associated protein
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