Chronic respiratory failure negatively affects speech function in patients with bulbar and spinal onset amyotrophic lateral sclerosis: retrospective data from a tertiary referral center

Background: Although dysarthria and respiratory failure are widely described in literature as part of the natural history of Amyotrophic lateral sclerosis (ALS), the specific interaction between them has been little explored. Aim: To investigate the relationship between chronic respiratory failure a...

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Published in:Logopedics, phoniatrics, vocology phoniatrics, vocology, 2024-04, Vol.ahead-of-print (ahead-of-print), p.1-10
Main Authors: Sarmet, Max, Santos, Dante Brasil, Mangilli, Laura Davison, Million, Janae Lyon, Maldaner, Vinicius, Zeredo, Jorge L.
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Anatomical systems
Dysarthria
Measures
neuromuscular disorders
Patients
Practitioner patient relationship
pulmonary function test
Respiratory failure
Speech disorders
Spirometry
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Summary:Background: Although dysarthria and respiratory failure are widely described in literature as part of the natural history of Amyotrophic lateral sclerosis (ALS), the specific interaction between them has been little explored. Aim: To investigate the relationship between chronic respiratory failure and the speech of ALS patients. Materials and methods: In this cross-sectional retrospective study we reviewed the medical records of all patients diagnosed with ALS that were accompanied by a tertiary referral center. In order to determine the presence and degree of speech impairment, the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) speech sub-scale was used. Respiratory function was assessed through spirometry and through venous blood gasometry obtained from a morning peripheral venous sample. To determine whether differences among groups classified by speech function were significant, maximum and mean spirometry values of participants were compared using multivariate analysis of variance (MANOVA) with Tukey's post hoc test. Results: Seventy-five cases were selected, of which 73.3% presented speech impairment and 70.7% respiratory impairment. Respiratory and speech functions were moderately correlated (seated FVC r = 0.64; supine FVC r = 0.60; seated FEV1 r = 0.59 and supine FEV1 r = 0.54, p 
ISSN:1401-5439
1651-2022
DOI:10.1080/14015439.2022.2092209