Up-regulation of BTN3A1 on CD14⁺ cells promotes Vγ9Vδ2 T cell activation in psoriasis

Vγ9Vδ2 T cells play an important role in the development and progression of psoriasis vulgaris (PV), but how they promote skin inflammation and the molecular mechanisms underlying Vγ9Vδ2 T cell dysfunction are poorly understood. Here, we show that circulating Vγ9Vδ2 T cells are decreased and exhibit...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2022-11, Vol.119 (44), p.1-10, Article e2117523119
Main Authors: Zhou, Jiaqing, Zhang, Jingjing, Tao, Lu, Peng, Kexin, Zhang, Qiaoan, Yan, Kexiang, Luan, Jing, Pan, Jiewen, Su, Xiaohui, Sun, Jiping, Zhang, Zhenghua, Shen, Lei
Format: Article
Language:English
Subjects:
Antigens
Antigens, CD
Biological Sciences
Butyrophilin
Butyrophilins - metabolism
CD14 antigen
Cell activation
Cell proliferation
Humans
Immunology and Inflammation
Lymphocyte Activation
Lymphocytes
Lymphocytes T
Molecular modelling
Monocytes
Photovoltaic cells
Psoriasis
Psoriasis vulgaris
Receptors, Antigen, T-Cell, gamma-delta
Skin diseases
Skin lesions
T-Lymphocytes
Therapeutic targets
Tumor Necrosis Factor-alpha
Tumor necrosis factor-α
Up-Regulation
γ-Interferon
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