CircCDR1as mediates PM 2.5 -induced lung cancer progression by binding to SRSF1

Research indicates that particulate matter with an aerodynamic equivalent diameter of less than or equal to 2.5 µm in ambient air may induce lung cancer progression. Circular RNAs are a special kind of endogenous noncoding RNA, and their functions are reflected in various diseases and physiological...

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Published in:Ecotoxicology and environmental safety 2023-01, Vol.249, p.114367
Main Authors: Xu, Jingbin, Huang, Lanyi, Bao, Tuya, Duan, Kaiqian, Cheng, Yu, Zhang, Haimin, Zhang, Yong, Li, Jing, Li, Qiujuan, Li, Fasheng
Format: Article
Language:English
Subjects:
A549 Cells
Animals
Cyclin D1 - genetics
Cyclin D1 - metabolism
Disease Models, Animal
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Mice
Particulate Matter - toxicity
RNA, Circular - metabolism
Serine-Arginine Splicing Factors - metabolism
Vascular Endothelial Growth Factor A - genetics
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Summary:Research indicates that particulate matter with an aerodynamic equivalent diameter of less than or equal to 2.5 µm in ambient air may induce lung cancer progression. Circular RNAs are a special kind of endogenous noncoding RNA, and their functions are reflected in various diseases and physiological processes, but there are still few studies related to PM -induced lung cancer. Here, we identified that circCDR1as was upregulated in lung cancer cells stimulated with PM and positively correlated with the malignant features of lung cancer. The lower expression of CircCDR1as reduced the adverse progression of lung cancer cells after PM treatment; the lower expression of circCDR1as impaired the growth size and metastatic ability of lung cancer cells in mouse tumour models. Mechanistically, circCDR1as specifically bound to serine/arginine-rich splicing Factor 1 (SRSF1) and affected the splicing of vascular endothelial growth factor-A (VEGFA) by SRSF1. Furthermore, circCDR1as affected SRSF1 function by regulating PARK2-mediated SRSF1 ubiquitination, protein production and degradation. CircCDR1as also affected C-myc and cyclin D1 expression by regulating SRSF1 and affecting the wnt/β-catenin signalling pathway, ultimately promoting malignant behavior and inhibiting the apoptosis of lung cancer cells, thereby causing PM -induced lung cancer development.
ISSN:1090-2414