A Phase 1 Trial of Durvalumab in Combination with Bacillus Calmette-Guerin (BCG) or External Beam Radiation Therapy in Patients with BCG-unresponsive Non-muscle-Invasive Bladder Cancer: The Hoosier Cancer Research Network GU16-243 ADAPT-BLADDER Study

Intravenous anti–PD-L1 durvalumab therapy can safely be combined with intravesical bacillus Calmette-Guerin (BCG) treatments or a short-course of bladder-focused external beam radiation therapy (6 Gy × 3) in BCG-unresponsive non–muscle-invasive bladder cancer patients. Encouraging preliminary effica...

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Bibliographic Details
Published in:	European urology 2023-06, Vol.83 (6), p.486-494
Main Authors:	Hahn, Noah M., O'Donnell, Michael A., Efstathiou, Jason A., Zahurak, Marianna, Rosner, Gary L., Smith, Jeff, Kates, Max R., Bivalacqua, Trinity J., Tran, Phuoc T., Song, Daniel Y., Baras, Alex S., Matoso, Andres, Choi, Woonyoung, Smith, Kellie N., Pardoll, Drew M., Marchionni, Luigi, McGuire, Bridget, Grace Phelan, Mary, Johnson, Burles A., O'Neal, Tanya, McConkey, David J., Rose, Tracy L., Bjurlin, Marc, Lim, Emerson A., Drake, Charles G., McKiernan, James M., Deutsch, Israel, Anderson, Christopher B., Lamm, Donald L., Geynisman, Daniel M., Plimack, Elizabeth R., Hallman, Mark A., Horwitz, Eric M., Al-Saleem, Essel, Chen, David Y.T., Greenberg, Richard E., Kutikov, Alexander, Guo, Gordon, Masterson, Timothy A., Adra, Nabil, Kaimakliotis, Hristos Z.
Format:	Article
Language:	English
Subjects:	Adjuvants, Immunologic Administration, Intravesical Bacillus Calmette-Guerin Bacillus Calmette-Guerin unresponsive BCG Vaccine - adverse effects Bladder cancer Clinical trial Durvalumab Humans Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - pathology Non-Muscle Invasive Bladder Neoplasms Non–muscle invasive PD-L1 Radiation Urinary Bladder - pathology Urinary Bladder Neoplasms - pathology Urothelial carcinoma
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