Combined contributions of cytochrome P450s (CYPs) and non-enzymatic metabolism in the in vitro biotransformation of anaprazole, a novel proton pump inhibitor

Anaprazole, a new proton pump inhibitor (PPI), is designed for the treatment of acid-related diseases, such as gastric ulcers and gastroesophageal reflux. This study explored the in vitro metabolic transformation of anaprazole. The metabolic stabilities of anaprazole in human plasma and human liver...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2023-08, Vol.396 (8), p.1759-1771
Main Authors: Liu, Fei, Xu, Yanjun, Wang, Li, Ma, Xifeng, Zhang, Zhen, Zhuang, Xiaomei
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Biotransformation
Chromatography
Cytochrome
Dealkylation
Dehydrogenation
Demethylation
Drug interaction
Enzyme inhibitors
Enzymes
Gastroesophageal reflux
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolic pathways
Metabolism
Metabolites
Microsomes
Neurosciences
Pharmacology/Toxicology
Proton pump inhibitors
Scientific imaging
Ulcers
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