Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration

Many neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing the levels of these proteins mitigates diseas...

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Bibliographic Details
Published in:	Autophagy reports 2023, Vol.2 (1)
Main Authors:	Benyair, Ron, Panapakkam Giridharan, Sai Srinivas, Rivero-Ríos, Pilar, Hasegawa, Junya, Bristow, Emily, Eskelinen, Eeva-Liisa, Shmueli, Merav D, Fishbain-Yoskovitz, Vered, Merbl, Yifat, Sharkey, Lisa M, Paulson, Henry L., Hanson, Phyllis I, Patnaik, Samarjit, Al-Ramahi, Ismael, Botas, Juan, Marugan, Juan, Weisman, Lois S.
Format:	Article
Language:	English
Subjects:	escrt huntingtin huntington multivesicular bodies (mvb) nct-504 neurodegeneration tau
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