Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

Introduction Epidemiological studies demonstrated that cleaning work and frequent use of cleaning products are risk factors for asthma. Laundry detergents have been reported to have epithelial barrier‐opening effects. However, whether laundry detergents directly induce airway inflammation and its me...

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Published in:	Allergy (Copenhagen) 2023-07, Vol.78 (7), p.1878-1892
Main Authors:	Saito, Kyoko, Orimo, Keisuke, Kubo, Terufumi, Tamari, Masato, Yamada, Ayako, Motomura, Kenichiro, Sugiyama, Hiroki, Matsuoka, Ryo, Nagano, Naoko, Hayashi, Yuka, Arae, Ken, Hara, Mariko, Ikutani, Masashi, Fukuie, Tatsuki, Sudo, Katsuko, Matsuda, Akio, Ohya, Yukihiro, Fujieda, Shigeharu, Saito, Hirohisa, Nakae, Susumu, Matsumoto, Kenji, Akdis, Cezmi A., Morita, Hideaki
Format:	Article
Language:	English
Subjects:	Animals antioxidants Asthma bronchial asthma Cell activation Cosmetics Detergents Detergents - adverse effects Dust environment Epidemiology Epithelial cells epithelium Flow cytometry group 2 innate lymphoid cells (ILC2) histology House dust Humans hygiene hypothesis Immunity, Innate Inflammation Interleukin-33 - pharmacology Laundry Leukocytes (eosinophilic) Lymphocytes Lymphoid cells Mice micelles Oxidative stress quantitative polymerase chain reaction RAG2 protein Respiratory tract Respiratory tract diseases risk Risk factors sodium dodecyl sulfate sodium dodecylbenzenesulfonate Sodium lauryl sulfate Surface-Active Agents - adverse effects Surfactants Western blotting
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