Rhythmic cilia changes support SCN neuron coherence in circadian clock

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2023-06, Vol.380 (6648), p.972-979
Main Authors: Tu, Hai-Qing, Li, Sen, Xu, Yu-Ling, Zhang, Yu-Cheng, Li, Pei-Yao, Liang, Li-Yun, Song, Guang-Ping, Jian, Xiao-Xiao, Wu, Min, Song, Zeng-Qing, Li, Ting-Ting, Hu, Huai-Bin, Yuan, Jin-Feng, Shen, Xiao-Lin, Li, Jia-Ning, Han, Qiu-Ying, Wang, Kai, Zhang, Tao, Zhou, Tao, Li, Ai-Ling, Zhang, Xue-Min, Li, Hui-Yan
Format: Article
Language:English
Subjects:
Animals
Biological clocks
Cilia
Cilia - metabolism
Circadian Clocks - genetics
Circadian Rhythm - physiology
Circadian rhythms
Gene expression
Hedgehog protein
Hedgehog Proteins - metabolism
Jet lag
Mice
Neurons
Signaling
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - physiology
Suprachiasmatic Nucleus Neurons
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