Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period

Changes in the function of inhibitory interneurons (INs) during cortical development could contribute to the pathophysiology of neurodevelopmental disorders. Using all-optical in vivo approaches, we find that parvalbumin (PV) INs and their immature precursors are hypoactive and transiently decoupled...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Mass.), 2023-09, Vol.111 (18), p.2863-2880.e6
Main Authors:	Kourdougli, Nazim, Suresh, Anand, Liu, Benjamin, Juarez, Pablo, Lin, Ashley, Chung, David T., Graven Sams, Anette, Gandal, Michael J., Martínez-Cerdeño, Verónica, Buonomano, Dean V., Hall, Benjamin J., Mombereau, Cédric, Portera-Cailliau, Carlos
Format:	Article
Language:	English
Subjects:	Animals autism spectrum disorders calcium imaging Disease Models, Animal Fragile X Messenger Ribonucleoprotein 1 - genetics Fragile X Syndrome - genetics Humans intellectual disability Interneurons - physiology Kv3.1 medial ganglionic eminence Mice Mice, Knockout Neurons - metabolism parvalbumin Parvalbumins - genetics Parvalbumins - metabolism RNA-seq tactile defensiveness Touch transcriptomics two-photon
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