Variability of contribution of 1,25 (OH) 2 D3 (vitamin D) level to hematopoietic stem cell transplantation outcome

• Published in: Clinical nutrition ESPEN 2023-12, Vol.58, p.355
• Main Authors: Kamel, Azza M, Radwan, Eman R, Zeidan, Ashraf, Zaky, Amen, Ibrahim, Abeer, Refaat, Ahmed, Abdelfattah, Raafat, Abdelfattah, Maged
• Format: Article
• Language: English
• Subjects: Bronchiolitis Obliterans Syndrome; Graft vs Host Disease - epidemiology; Hematopoietic Stem Cell Transplantation; Humans; Vitamin D; Vitamin D Deficiency
• ISSN: 2405-4577

The impact of vitamin D status on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) has recently been the focus of interest with a lot of controversy. In this study we aimed to evaluate the impact of pre-transplant vit. D level on the outcome of HSCT. In this study, we evaluated the impact of vitamin D level on the risk of development of graft versus host disease (GVHD) and survival after HSCT. The study included 97 patients who received allogeneic HSCT from an identical sibling. Serum vitamin D level was measured before conditioning using ELIZA. Student t-test, Mann-Whitney U test, ANOVA F-test and Kruskal-Wallis H tests were used to determine significance of difference for quantitative data. Pearson correlation, Spearman correlation and Chi-square test were used to determine correlations and associations. Kaplan-Meier and Log rank (Mantel-Cox) tests were used for analysis of survival. P value ≤ 0.05 was considered significant. Vitamin D level showed a range of 18.24-84.6 with a mean of 38.14 ± 9.73 and a median of 36.26 ng/ml. Two patients had vitamin D level