A main chain biodegradable polyurethane with anti-protein adsorption and anti-bacterial adhesion performances

Biofilms are initially formed by substances such as proteins secreted by bacteria adhering to a surface. To achieve a durable antibacterial material, biodegradable dihydroxyl-terminated poly[(ethylene oxide)- co -(ethylene carbonate)] (PEOC(OH) 2 ) with anti-protein adsorption properties was synthes...

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Bibliographic Details
Published in:Soft matter 2023-12, Vol.2 (1), p.192-2
Main Authors: Cao, Zhonglin, Ma, Chunfeng, Xiang, Li, Cao, Linyan
Format: Article
Language:English
Subjects:
Adhesion
Adsorption
Antibacterial materials
Bacteria
Biodegradation
Biofilms
Chemical synthesis
Diisocyanates
Ethylene oxide
Liquid culture
Microorganisms
NMR
Nuclear magnetic resonance
Polyethylene glycol
Polypropylene
Polypropylene glycol
Polyurethane
Polyurethane resins
Protein adsorption
Proteins
Quartz crystal microbalance
Quartz crystals
Segments
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Summary:Biofilms are initially formed by substances such as proteins secreted by bacteria adhering to a surface. To achieve a durable antibacterial material, biodegradable dihydroxyl-terminated poly[(ethylene oxide)- co -(ethylene carbonate)] (PEOC(OH) 2 ) with anti-protein adsorption properties was synthesized in this study. Further polycondensation of PEOC(OH) 2 and isophorone diisocyanate (IPDI) led to biodegradable polyurethane (PEOC-PU) with PEOC as the soft segment. For comparison, polyurethanes with polyethylene glycol (PEG-PU) and polypropylene glycol (PPG-PU) as soft segments were also synthesized. The chemical structures of the polyurethanes were characterized by 1 H NMR and FTIR. The biodegradation behavior of PEOC-PU promoted by lipase due to the presence of ethylene carbonate units was also studied. Their resistance to proteins was studied using quartz crystal microbalance with dissipation (QCM-D) and the results revealed that PEOC-PU exhibited excellent nonspecific resistance to proteins. The colonization of microorganisms on PU in the liquid culture medium was further examined and the results showed that PEOC-PU exhibited excellent antibacterial adhesion performance due to its protein resistance and biodegradation. A biodegradable PEOC-PU coating, a self-renewable material, presented outstanding nonspecific resistance to proteins and antibacterial adhesion, and could be hopefully used in medical antibacterial dressings.
ISSN:1744-683X
1744-6848
DOI:10.1039/d3sm01344h