Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed, resulting in variants with substantial growth advantages, such as E...

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Published in:	PLoS pathogens 2023-12, Vol.19 (12), p.e1011868
Main Authors:	Jian, Fanchong, Feng, Leilei, Yang, Sijie, Yu, Yuanling, Wang, Lei, Song, Weiliang, Yisimayi, Ayijiang, Chen, Xiaosu, Xu, Yanli, Wang, Peng, Yu, Lingling, Wang, Jing, Liu, Lu, Niu, Xiao, Xiao, Tianhe, An, Ran, Wang, Yao, Gu, Qingqing, Shao, Fei, Jin, Ronghua, Shen, Zhongyang, Wang, Youchun, Wang, Xiangxi, Cao, Yunlong
Format:	Article
Language:	English
Subjects:	ACE2 Amino acids Analysis Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - genetics Antibodies Antibodies, Neutralizing Binding Biology and life sciences Convergence (Biology) Coronaviruses COVID-19 COVID-19 - genetics COVID-19 Serotherapy Epistasis Evolution Glycoproteins Health aspects Humans Infections Medicine and health sciences Mutation Neutralization Plasma Receptors Research and Analysis Methods SARS-CoV-2 - genetics Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Testing Viral antibodies Viral diseases
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