Rationality of the ethanol precipitation process in modern preparation production of Zishui‐Qinggan decoction evaluated by integrating UPLC‐QTOF‐MS/MS‐based chemical profiling/serum pharmacochemistry and network pharmacology

Introduction Zishui‐Qinggan decoction (ZQD) is a classical traditional Chinese medicine formula (TCMF) for alleviating menopausal symptoms (MPS) induced by endocrine therapy in breast cancer patients. In the production of TCMF modern preparations, ethanol precipitation (EP) is a commonly but not ful...

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Bibliographic Details
Published in:Phytochemical analysis 2024-06, Vol.35 (4), p.733-753
Main Authors: Wu, Cheng‐Ying, Guo, Yi‐Yin, Ma, Zhen‐Yue, Zhou, Jing, Long, Fang, Shen, Hong, Xu, Jin‐Di, Zhou, Shan‐Shan, Huo, Jie‐Ge, Hu, Can‐Hong, Li, Song‐Lin
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
AKT1 protein
blood serum
Breast cancer
breast neoplasms
Chemical precipitation
Effectiveness
Endocrine therapy
Ethanol
ethanol precipitation
Herbal medicine
Liquid chromatography
MAP kinase
Mass spectrometry
Mass spectroscopy
menopausal syndrome
menopause
network pharmacology
Oral administration
Oriental traditional medicine
Pharmacology
phytochemicals
Quadrupoles
serum pharmacochemistry
Signal transduction
tandem mass spectrometry
Target recognition
therapeutics
Traditional Chinese medicine
UPLC‐QTOF‐MS/MS
Zishui‐Qinggan decoction
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