Healthy Tendon Stem Cell‐Derived Exosomes Promote Tendon‐To‐Bone Healing of Aged Chronic Rotator Cuff Tears by Breaking the Positive‐Feedback Cross‐Talk between Senescent Tendon Stem Cells and Macrophages through the Modulation of Macrophage Polarization

The re‐tear rate of rotator cuff tears (RCT) after surgical repair is high, especially in aged patients with chronic tears. Senescent tendon stem cells (s‐TSCs) generally exist in aged and chronically torn rotator cuff tendons and are closely associated with impaired tendon‐to‐bone healing results....

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-08, Vol.20 (31), p.e2311033-n/a
Main Authors: Zhang, Xuancheng, Song, Wei, Liu, Yang, Han, Kang, Wu, Yuxu, Cho, Eunshinae, Fang, Zhaoyi, Jiang, Lianghua, Hu, Yihe, Zhu, Xuesong, Jiang, Jia, Huangfu, Xiaoqiao, Zhao, Jinzhong
Format: Article
Language:English
Subjects:
Animals
Bone and Bones
Cellular Senescence
Exosomes - metabolism
Feedback
Gene sequencing
Genotype & phenotype
Healing
healthy tendon stem cell‐derived exosomes (h‐TSC‐Exos)
Humans
Macrophages
Macrophages - metabolism
Male
Polarization
Positive feedback
Rats
Rats, Sprague-Dawley
Rotator cuff
Rotator Cuff - pathology
Rotator Cuff Injuries - metabolism
Rotator Cuff Injuries - pathology
rotator cuff tears (RCT)
Senescence
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
Tearing
Tendons
Tendons - pathology
tendon‐to‐bone healing
Wound Healing
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