Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice

Endovascular middle cerebral artery occlusion (MCAO) is a widely used experimental ischemic stroke model. However, the model carries high early mortality. Our aim was to investigate the factors that influence early mortality within 48 h of reperfusion after transient MCAO. Using C57BL/6 mice, we ind...

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Bibliographic Details
Published in:Experimental neurology 2024-10, Vol.380, p.114903-114903, Article 114903
Main Authors: Jin, Xuyan, Imai, Takahiko, Morais, Andreia, Sasaki, Yuichi, Chung, David Y., Ayata, Cenk
Format: Article
Language:English
Subjects:
Animals
Brain Infarction - etiology
Brain Infarction - pathology
Disease Models, Animal
Early mortality
Endovascular Procedures
hippocampus
Hippocampus - pathology
Infarction
Infarction, Middle Cerebral Artery - mortality
Infarction, Middle Cerebral Artery - pathology
Ischemic stroke
Male
Mice
Mice, Inbred C57BL
Seizure
Seizures - etiology
Seizures - mortality
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