Chondroitin sulfate sponge scaffold for slow-release Mg 2+ /Cu 2+ in diabetic wound management: Hemostasis, effusion absorption, and healing

The management of diabetic wounds presents significant challenges due to persistent inflammation, microenvironmental disruptions, and impaired angiogenesis. To address these issues, this study developed a multifunctional chondroitin sulfate sponge (CSP@Cu-Mg) with anti-inflammatory properties, hemos...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2024-12, Vol.282 (Pt 6), p.137561
Main Authors: Zhu, Fengyi, Wen, Qiulan, Hu, Yuting, Gong, Jun, Zhang, Xibing, Huang, Chaoyang, Zhou, Hai, Chen, Lianglong, Yu, Li
Format: Article
Language:English
Subjects:
Animals
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - pharmacology
Copper - chemistry
Copper - pharmacology
Delayed-Action Preparations - pharmacology
Diabetes Mellitus, Experimental - complications
Hemostasis - drug effects
Humans
Magnesium - chemistry
Magnesium - pharmacology
Male
Mice
Porosity
Rats
Tissue Scaffolds - chemistry
Wound Healing - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The management of diabetic wounds presents significant challenges due to persistent inflammation, microenvironmental disruptions, and impaired angiogenesis. To address these issues, this study developed a multifunctional chondroitin sulfate sponge (CSP@Cu-Mg) with anti-inflammatory properties, hemostatic effects, effusion absorption, and enhanced healing promotion. Through ion crosslinking, MgO and CuO were incorporated into the interpenetrating network structure of chondroitin sulfate and acellular dermal matrix, resulting in a sponge with impressive liquid absorption capacity (3450 %) and porosity (83 %). This sponge enabled sustained release of Mg /Cu ions, with approximately 40 % cumulative release over 7 days. This release helped reduce inflammation, promote the proliferation and migration of skin repair-related cells, and stimulate angiogenesis. In vivo studies demonstrated that the CSP@Cu-Mg sponge significantly improved diabetic wound healing by modulating inflammation and accelerating collagen deposition, angiogenesis, and re-epithelialization. This extracellular matrix sponge, which synergistically releases Mg /Cu , presents a promising strategy for comprehensive diabetic wound management with substantial clinical implications.
ISSN:1879-0003