Activation of Strong π–Acids at [Fe4S4]+ Clusters Enabled by a Noncanonical Electronic Structure

• Published in: Journal of the American Chemical Society 2024-12, Vol.146 (49), p.34080-34091
• Main Authors: Brown, Alexandra C., Thompson, Niklas B., Suess, Daniel L. M.
• Format: Article
• Language: English
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/jacs.4c13490

Although Fe–S clusters are privileged metallocofactors for the reduction of N2, CO, and other π-acidic substrates, their constituent metal ionshigh-spin Fe2+ and Fe3+are typically not amenable to binding and activating strong π-acids. Here, we demonstrate that [Fe4S4]+ clusters can overcome this limitation by adopting a noncanonical electronic structure. Specifically, we report the synthesis and characterization of a series of 3:1 site-differentiated [Fe4S4]+ clusters in which the unique Fe site is bound by one of 10 electronically variable arylisocyanide ligands. Rather than being continuously tuned as a function of the arylisocyanides’ electronic properties (e.g., as quantified by linear free energy relationships), the structures of the clusters are divided into two groups: (i) those with moderately π-acidic isocyanides, which adopt a “typical” structure characterized by standard bond metrics and geometric distortions from tetrahedral symmetry, and (ii) those with more strongly π-acidic isocyanides, which adopt a “contracted” structure with an unusually symmetric geometry and a compressed cluster core. Computational studies revealed that although the “typical” structure has a canonical electronic structure, the “contracted” structure has a noncanonical arrangement of spin density, with a full complement of π-backbonding electrons and more substantial Fe–Fe delocalization. These features of the “contracted” structure enable substantial CN bond weakening of the strongest π-acceptors in the series. More generally, the experimental characterization of the “contracted” electronic isomer suggests that other noncanonical electronic structures of Fe–S clusters remain to be discovered.