Cost-effectiveness of vector control for supplementing mass drug administration for eliminating lymphatic filariasis in India

Despite progress using mass drug administration (MDA), lymphatic filariasis (LF) remains a major public health issue in India. Vector control could potentially augment MDA towards LF elimination. We conducted a cost-effectiveness analysis of MDA alone and MDA together with vector control single (VCS...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2024-12, Vol.18 (12), p.e0011835
Main Authors: Shepard, Donald S, Lwin, Aung K, Pulikkottil, Sunish I, Kalimuthu, Mariapillai, Arunachalam, Natarajan, Tyagi, Brij K, White, Graham B
Format: Article
Language:English
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Summary:Despite progress using mass drug administration (MDA), lymphatic filariasis (LF) remains a major public health issue in India. Vector control could potentially augment MDA towards LF elimination. We conducted a cost-effectiveness analysis of MDA alone and MDA together with vector control single (VCS) modality or vector control integrated (VCI) modalities. Data came from historical controls and a three-arm cluster randomized trial of 36 villages at risk of LF transmission in Tamil Nadu, India. The arms were: MDA alone (the standard of care); MDA plus VCS (expanded polystyrene beads covering the water surface in wells and cesspits to suppress the filariasis vector mosquito Culex quinquefasciatus); and MDA plus VCI (VCS plus insecticidal pyrethroid-impregnated curtains [over windows, doors, and eaves). Economic costs in 2010 US$ combined government and community inputs from household to state levels. Outcomes were controlled microfilaria prevalence (MfP) and antigen prevalence (AgP) to conventional elimination targets (MfP
ISSN:1935-2735