Preclinical and First-In-Human Imaging of Novel [18F]F-FAPI-FUSCC-07 Tracer: Comparative Prospective Study with [18F]F-FAPI-42 and [18F]F-FAPI-74

This study aimed to develop and evaluate a novel fibroblast activation protein (FAP)-specific tracer, fluorine-18-labeled fibroblast activation protein inhibitor-FUSCC-07 ([18F]­F-FAPI-FUSCC-07), for use in both preclinical and clinical settings. Preclinical evaluations were conducted to assess the...

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Bibliographic Details
Published in:Molecular pharmaceutics 2025-03, Vol.22 (3), p.1624-1632
Main Authors: Bian, Linjie, Liu, Xinyu, Wang, Xiao, Sun, Yuyun, Du, Xinyue, Gu, Bingxin, Xu, Xiaoping, Song, Shaoli
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Endopeptidases
Female
Fluorine Radioisotopes - chemistry
Glioma - diagnostic imaging
Humans
Male
Membrane Proteins - antagonists & inhibitors
Membrane Proteins - metabolism
Mice
Mice, Nude
Positron Emission Tomography Computed Tomography - methods
Prospective Studies
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - pharmacokinetics
Tissue Distribution
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