Impaired Resting-State Functional Connectivity in Cerebral Autosomal-Dominant Arteriopathy, Subcortical Infarcts, and Leukoencephalopathy Mutant Mice

BACKGROUND: Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy is the most prevalent monogenic inherited cause of cerebral small vessel disease. Despite its prevalence, there is currently no proven therapy to prevent or reverse the progression of the disease. MET...

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Bibliographic Details
Published in:Stroke (1970) 2025-04, Vol.56 (4), p.987-995
Main Authors: Aykan, Sanem Aslihan, Lai, James Han, Sugimoto, Kazutaka, Aykan, Orhan, Fung, Wai Yee, Ho, David, Joutel, Anne, Sakadzic, Sava, Chung, David Y., Ayata, Cenk
Format: Article
Language:English
Subjects:
Animals
CADASIL - diagnostic imaging
CADASIL - drug therapy
CADASIL - genetics
CADASIL - pathology
CADASIL - physiopathology
Corpus Callosum - pathology
Disease Models, Animal
Female
Leukoencephalopathies - genetics
Leukoencephalopathies - physiopathology
Male
Mice
Mice, Transgenic
Mutation
Receptor, Notch3 - genetics
Tocotrienols - pharmacology
White Matter - physiopathology
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