B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function

Liver regeneration (LR) is essential for recovery from acute trauma, cancer surgery, or transplantation. Neurotransmitters such as acetylcholine (ACh) play a role in LR by stimulating immune cells and augmenting hepatocyte proliferation, but the source of this ACh remains unclear. Here, we demonstra...

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Published in:	Immunity (Cambridge, Mass.) Mass.), 2025-05, Vol.58 (5), p.1201-1216.e7
Main Authors:	Modares, Nastaran Fazel, Hendrikse, Liam D., Smith, Logan K., Paul, Michael St, Haight, Jillian, Luo, Ping, Liu, Shaofeng, Fortin, Jerome, Tong, Frances K., Wakeham, Andrew C., Jafari, Soode Moghadas, Zheng, Chunxing, Buckland, Mackenzie, Flick, Robert, Silvester, Jennifer, Berger, Thorsten, Ketela, Troy, Helke, Simone, Foffi, Erica, Niavarani, Raheleh, Mcwilliam, Ryan, Saunders, Mary E., Colonna, Isabelle, David, Bruna Araujo, Rastogi, Tashi, Lee, Woo-Yong, Kubes, Paul, Mak, Tak W.
Format:	Article
Language:	English
Subjects:	acetylcholine Acetylcholine - metabolism alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals B cells B-Lymphocytes - immunology B-Lymphocytes - metabolism CD8 T cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism ChAT B cells Choline O-Acetyltransferase - genetics Choline O-Acetyltransferase - metabolism Hepatectomy hepatic repair IL-6 Interferon-gamma - metabolism Kupffer cells Kupffer Cells - immunology Kupffer Cells - metabolism Liver - immunology Liver - metabolism liver regeneration Liver Regeneration - immunology Male Mice Mice, Inbred C57BL Mice, Knockout partial hepatectomy α7 nAChR α7 nicotinic acetylcholine receptor
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