Large-scale prediction shows that the dominant structure of the HIV-1 domain closed by the U5-AUG duplex contains the alternative SD a hairpin, and the domain variant without SD is rare

Using several models of the HIV-1 5' leader, it was shown that the domain containing the structural elements that regulate the processes of dimerization and genome packaging, as well as the initiation of reverse transcription, is closed by the U5-AUG duplex. However, there is no consensus in th...

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Bibliographic Details
Published in:Virus research 2025-07, Vol.357, p.199581
Main Authors: Zarudnaya, M I, Potyahaylo, A L, Gorb, L G
Format: Article
Language:English
Subjects:
5' Untranslated Regions
Genome, Viral
HIV-1 - chemistry
HIV-1 - genetics
Humans
Nucleic Acid Conformation
RNA, Viral - chemistry
RNA, Viral - genetics
Online Access:Get full text
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