Combining epidemiology, network toxicology and in vivo experimental validation to uncover takeout-mediated DEHP/MEHP toxicity in inflammatory bowel disease

Mono (2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a widely used plasticizer in food packaging materials. While DEHP/MEHP has been linked to various health risks, the underlying mechanisms between DEHP/MEHP exposure and inflammatory bowel disease (I...

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Bibliographic Details
Published in:Free radical biology & medicine 2025-11, Vol.239, p.1-13
Main Authors: Li, Jiaxin, Zhang, Hong, Li, Xi, Chen, Kexin, Wu, Yushan, Jiang, Mingshan, Zeng, Zhen, Ma, Chunxiang, Yin, Fang, Li, Yan, Pang, Jiangmei, Lin, Hao, Chen, Jingjing, Lv, Minghua, Xiang, Zou, Zhang, Hu
Format: Article
Language:English
Subjects:
Adult
Animals
Colitis - chemically induced
Colitis - pathology
Diethylhexyl Phthalate - analogs & derivatives
Diethylhexyl Phthalate - toxicity
Female
Genome-Wide Association Study
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - chemically induced
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - genetics
Inflammatory Bowel Diseases - pathology
Male
Mendelian randomization
Mice
Middle Aged
Molecular Docking Simulation
Mono(2-ethylhexyl) phthalate
National health and nutrition examination Survey
Network toxicology
Nutrition Surveys
Plasticizers - toxicity
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