Characterization of the tumor immune microenvironment in pregnancy-associated breast cancer through multiplex immunohistochemistry and transcriptome analyses

Background Pregnancy-associated breast cancer (PABC) is breast cancer diagnosed during pregnancy or within 2 years postpartum. Although relatively rare, it is associated with a poor prognosis, and the underlying mechanisms contributing to this unfavorable condition remain incompletely understood. In...

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Published in:	Breast cancer research : BCR 2025-08, Vol.27 (1), p.154-10, Article 154
Main Authors:	Chen, Ching-Hsuan, Chen, I-Chun, Hsu, Chia-Lang, Lu, Tzu-Pin, Wang, Ming-Yang, Tsai, Li-Wei, Huang, Chiun-Sheng, Lu, Yen-Shen, Lin, Ching-Hung
Format:	Article
Language:	English
Subjects:	Adult Approximation B cells Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer Research CD163 antigen CD20 antigen CD4 antigen CD8 antigen Cloning Cytotoxicity Diagnosis Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immune microenvironment Immunohistochemistry Immunohistochemistry - methods Lactation Lymphocytes Lymphocytes B Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Macrophages Medical diagnosis Medical prognosis Metastases Middle Aged Oncology Oncology, Experimental Pathology Patients Physiology Postpartum Postpartum period Pregnancy Pregnancy Complications, Neoplastic - genetics Pregnancy Complications, Neoplastic - immunology Pregnancy Complications, Neoplastic - metabolism Pregnancy Complications, Neoplastic - pathology Pregnant women Prognosis Retrospective Studies Software Surgical Oncology Survival analysis T cells Transcriptome Transcriptomes Transcriptomics Tumor microenvironment Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumor-infiltrating lymphocytes Weaning Womens health
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