[68Ga]Ga-HM or [68Ga]Ga-PM: Which Is Superior for PET/CT Imaging of HMGB1-Positive Tumors?

High mobility group box 1 (HMGB1) is highly expressed in various malignancies and has been considered as a promising molecular target for cancer diagnosis and therapy. In this study, two novel peptide-based radiotracers targeting HMGB1 were synthesized, each achieving high radiochemical purity (>...

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Bibliographic Details
Published in:Molecular pharmaceutics 2025-10, Vol.22 (10), p.6279-6289
Main Authors: Wang, Kunyao, Zhao, Wenqi, Xu, Xiaozhang, Liang, Ting, Zhang, Chao, Tao, Weijing, Li, Xin, Gao, Feng
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Gallium Radioisotopes - chemistry
HMGB1 Protein - metabolism
Humans
Male
Mice
Mice, Nude
Neoplasms - diagnostic imaging
PC-3 Cells
Positron Emission Tomography Computed Tomography - methods
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - pharmacokinetics
Tissue Distribution
Citations: Items that this one cites
Online Access:Get full text
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