Glycoprotein Ib-CD11b + monocyte-derived macrophages mediate atherosclerosis-exacerbated psoriatic inflammation

Psoriasis is a systemic inflammatory skin disease affecting 2–3 % of the global population, with significant cardiovascular comorbidities. A complex inflammatory interaction exists between psoriasis and atherosclerosis, but the exact mechanism remains unclear. To elucidate this relationship, we coll...

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Bibliographic Details
Published in:Life sciences (1973) 2025-11, Vol.380, p.123960, Article 123960
Main Authors: Dong, Canbin, Yang, Wenjing, Sun, Lianxi, Lin, Jui-Ming, Wang, Jie, Wang, Yilun, Lin, Lanmei, Zhu, Xinyi, Huang, Jia, Lu, Xiaonian, Zhu, Junhao, Xu, Jinhua, Tan, Jinyun, Zhu, Ningwen, Du, Juan
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - immunology
Atherosclerosis - metabolism
Atherosclerosis - pathology
CD11b
CD11b Antigen - metabolism
Disease Models, Animal
Female
Glycoprotein Ib
Humans
Imiquimod
Inflammation - metabolism
Inflammation - pathology
Macrophages - immunology
Macrophages - metabolism
Macrophages - pathology
Male
Mice
Mice, Inbred C57BL
Monocyte
Monocytes - metabolism
Platelet
Platelet Glycoprotein GPIb-IX Complex - metabolism
Psoriasis
Psoriasis - complications
Psoriasis - immunology
Psoriasis - metabolism
Psoriasis - pathology
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