Effect of Cardioprotection on the Right Ventricular Function in Breast Cancer Patients Receiving Potentially Cardiotoxic Therapy: A SAFE Trial Substudy

Purpose To evaluate the effects of cardioprotective therapy (CPT) with neurohormonal inhibitors on cancer therapeutics–related cardiac dysfunction (CTRCD) in breast cancer patients, focusing on right ventricular (RV) function. Methods This is a secondary analysis of SAFE study, a randomized, phase 3...

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Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2025-09, Vol.42 (9), p.e70291-n/a
Main Authors: Del Bene, Maria Riccarda, Meattini, Icro, Pilato, Giuseppe, Becherini, Carlotta, Martella, Francesca, Salvestrini, Viola, Marrazzo, Livia, Saieva, Calogero, Olivotto, Iacopo, Barletta, Giuseppe, Livi, Lorenzo
Format: Article
Language:English
Subjects:
3D echocardiography
Adult
Aged
anthracycline
Antineoplastic Agents - adverse effects
Bisoprolol - pharmacology
Bisoprolol - therapeutic use
breast cancer
Breast Neoplasms - drug therapy
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Cardiotoxicity - etiology
Cardiotoxicity - physiopathology
Cardiotoxicity - prevention & control
chemotherapy‐induced cardiotoxicity
Double-Blind Method
Echocardiography - methods
Female
Heart Ventricles - diagnostic imaging
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Humans
Middle Aged
neurohormonal inhibitors
Original
Ramipril - pharmacology
Ramipril - therapeutic use
right ventricular function
Ventricular Dysfunction, Right - chemically induced
Ventricular Dysfunction, Right - diagnostic imaging
Ventricular Dysfunction, Right - physiopathology
Ventricular Dysfunction, Right - prevention & control
Ventricular Function, Right - drug effects
Ventricular Function, Right - physiology
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