Anthocyanin-functionalized selenocysteine nanotherapeutics alleviate cisplatin nephrotoxicity by inhibiting oxidative stress and ferroptosis

Although cisplatin (CDDP) remains a widely used chemotherapeutic agent in clinical cancer treatment, severe oxidative stress and inflammatory responses induced by CDDP are still major causes of acute kidney injury (AKI) in patients. Our previous studies have demonstrated that anthocyanins and seleno...

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Bibliographic Details
Published in:	Journal of nanobiotechnology 2025-11, Vol.23 (1), p.703-17, Article 703
Main Authors:	Zhu, Hongyan, Wu, Xingyuan, Tan, Yulin, Shi, Lei, Bai, Weibin, Li, Xiaoling
Format:	Article
Language:	English
Subjects:	Acute kidney injury Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Analysis Animals Anthocyanins Anthocyanins - chemistry Anthocyanins - pharmacology Anti-inflammatory agents Antimitotic agents Antineoplastic Agents Antioxidants Apoptosis Bioavailability Biomaterials Biotechnology Cancer Cancer therapies CD4 antigen Cell cycle Cell Line Chemistry Chemistry and Materials Science Chemotherapy Cisplatin Cisplatin - adverse effects Cisplatin - toxicity Cyanidin-3-O-glucoside Cytotoxicity Dosage and administration Ferroptosis Ferroptosis - drug effects Flow cytometry Free radicals Health aspects Humans Hydration Inflammation Inflammatory response Kidney - drug effects Kidneys Lymphocytes Lymphocytes T Macrophages Male MAP kinase Metabolism Mice Mice, Inbred C57BL Molecular Medicine Nanoparticles Nanoparticles - chemistry Nanotechnology Oxidative stress Oxidative Stress - drug effects Patient outcomes Selenocysteine Synthesis Toxicity
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