Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease

Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identify a replication enhancing domain (ReED) in non-structural protein 5A conferring high replication fitness to clinical isolates. Accumulation of mut...

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Bibliographic Details
Published in:Nature communications 2025-12, Vol.16 (1), p.10948-18
Main Authors: Rothhaar, Paul, Arand, Tomke, Seong, Ha Gyu-Thomas, Heuss, Christian, Tulessin, Margaret, Wang, Zhiqing, Förster, Colin, Schneider, Alina C, Quistrebert, Jocelyn, Chai, Haiting, Reineke, Marvin, Benning, Louise, Honegger, Jonathan, Hofmann, Maike, Thimme, Robert, Timm, Jörg, Schnitzler, Paul, Merle, Uta, Shoukry, Naglaa H, Bruneau, Julie, Rodrigo, Chaturaka, Lloyd, Andrew, Bull, Rowena A, Ansari, M Azim, Mogler, Carolin, McLauchlan, John, Forns, Xavier, Pérez-Del-Pulgar, Sofía, Lohmann, Volker
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - virology
Cell culture
Clinical isolates
Cloning
Coinfection
Efficiency
Female
Fitness
Genetic Variation
Genome, Viral
Genomes
Hepacivirus - genetics
Hepacivirus - pathogenicity
Hepacivirus - physiology
Hepatitis
Hepatitis C
Hepatitis C - immunology
Hepatitis C - virology
Hepatocellular carcinoma
HIV Infections - complications
HIV Infections - virology
Humans
Immune response
Immunocompromised Host
Immunocompromised hosts
Liver
Liver cancer
Liver Neoplasms - virology
Liver Transplantation
Male
Mutation
Pathogenesis
Patients
Phylogenetics
Proteins
Replication
RNA-Dependent RNA Polymerase
Transplants & implants
Viral Nonstructural Proteins - genetics
Virus Replication - genetics
Viruses
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