BoAHV-1 and −5 differentially modulate TLR3 signaling and type I IFN in neural cells

Varicellovirus bovinealpha (BoAHV)-1 and −5 (formerly known as bovine alphaherpesviruses 1 and 5) are closely-related neurotropic viruses with distinct neuropathogenic potential. In this study, we investigated how BoAHV-1 and BoAHV-5 modulate toll-like receptor 3 (TLR3) signaling pathway and type I...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2026-01, Vol.291, p.111046, Article 111046
Main Authors: Rosales, Juan José, Brunner, María Belén, Junco, Milagros, Cuesta, Lucía Martínez, Marin, Maia, Pérez, Sandra
Format: Article
Language:English
Subjects:
agonists
Animals
Cattle
Herpesvirus 1, Bovine - immunology
immune response
Immunity, Innate
immunopathology
innate immunity
Interferon Regulatory Factor-3 - genetics
Interferon Type I - immunology
Interferon Type I - metabolism
interferons
IRF-3
Neural cells
Neurons - immunology
Neurons - virology
NF-kappa B - genetics
NF-κB
Poly I-C - pharmacology
polyinosinic-polycytidylic acid
Signal Transduction - immunology
TLR3
Toll-like receptor 3
Toll-Like Receptor 3 - genetics
Toll-Like Receptor 3 - immunology
Toll-Like Receptor 3 - metabolism
TRIF
Type I IFN
Varicellovirus
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