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Over two decades of research place soluble oligomers of the amyloid beta peptide (AβOs) as pathological drivers of Alzheimer's disease. In animal models AβOs cause memory dysfunction as well as synapse loss, tau hyperphosphorylation, neuroinflammation, and selective neuron death. How pathologic...

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Bibliographic Details
Published in:Alzheimer's & dementia 2025-12, Vol.21 Suppl 7, p.e108372
Main Authors: Leon, Omar Orlando De, Nowar, Raghd, Jerisha, Josh, Campos, Raquel De, Viola, Kirsten L, Cline, Erika N, Klein, William L
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Amyloid beta-Peptides - immunology
Amyloid beta-Peptides - metabolism
Amyloid beta-Peptides - ultrastructure
Animals
Brain - metabolism
Brain - pathology
Chromatography, Affinity
Humans
Mice
Microscopy, Atomic Force
Online Access:Get full text
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