Drug Development

Alzheimer's disease (AD), particularly its autosomal dominant form (ADAD), presents unique challenges for drug development. Clinical trials involving cognitively healthy individuals with ADAD can provide a useful model for sporadic Alzheimer's disease. They can aid in studying the early st...

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Bibliographic Details
Published in:Alzheimer's & dementia 2025-12, Vol.21 Suppl 5, p.e100956
Main Authors: Pedretti, Nicolo Foppa, Karten, Yashmin, Zhang, Yi, Klein, Gregory, Tariot, Pierre N, Insel, Philip S, Su, Yi, Alexander, Robert C, Reiman, Eric M, Tatton, Nadine
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Amyloid beta-Peptides - metabolism
Antibodies, Monoclonal, Humanized - therapeutic use
Brain - diagnostic imaging
Brain - drug effects
Brain - metabolism
Brain - pathology
Disease Progression
Drug Development
Female
Humans
Male
Middle Aged
Presenilin-1 - genetics
tau Proteins - metabolism
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