p‑Terphenyls from the Fruiting Bodies of Boletopsis leucomelas with Neuroprotective, Anti-Neuroinflammatory, and Antioxidant Activities

Boletopsis leucomelasis a widely consumed edible mushroom with a dark-gray fruiting body. Four new p-terphenyls (1–4, boletamins A–D), one previously reported compound without detailed characterization (5, boletamin E), and seven known compounds (6–12) were isolated from its fruiting body and struct...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry 2026-01, Vol.74 (1), p.952-967
Main Authors:	Le, Tam Thi, Tran, Son Hung, Lee, Sohyun, Ko, Hyejin, Cha, Jin Wook, Park, Jin-Soo, Nguyen, Hai Yen, Kim, Won Kyu, Kang, Kyungsu, Jung, Sang Hoon
Format:	Article
Language:	English
Subjects:	Agaricales - chemistry Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology antioxidants Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Basidiomycota - chemistry Bioactive Constituents, Metabolites, and Functions Boletopsis Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - immunology Cell Line Cyclooxygenase 2 - genetics Cyclooxygenase 2 - immunology dietary supplements food chemistry Fruiting Bodies, Fungal - chemistry Humans Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - immunology Mice Microglia - drug effects Microglia - immunology Molecular Docking Simulation Molecular Structure mushrooms neurons Neurons - drug effects Neurons - immunology Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - immunology NF-kappa B - genetics NF-kappa B - immunology pharmacology Pseudomonas aeruginosa toxicity
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