Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11-ßhydroxysteroid dehydrogenase type 1 (11-ßHSD1) that regenerates active glucocorticoids from circulating metabolites. Glucocorticoids initially protect cardiomyocytes and p...

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Bibliographic Details
Published in:	British journal of pharmacology 2025-12
Main Authors:	Al Disi, Sara, Ascione, Raimondo, Khan, Shazia, Johnson, Thomas, Sammut, Eva, Bruno, Vito Domenico, Baz Lopez, Daniel, James, Carol‐Anne, Simpson, Joanna, Homer, Natalie Z., Millar, Michael, Singh, Trisha, von Kreigsheim, Alex, Mills, Nick L., Walker, Brian R., Andrew, Ruth, Webster, Scott P., Whittaker, Andrew, Freeman, Adrian, Gray, Gillian A.
Format:	Article
Language:	English
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