A Vibrational Analysis of Pyridoxal 5′-Phosphate Derivatives: Pyridoxal 5′-Phosphate-isopropylamine and Pyridoxal 5′-Phosphate‑(S)‑1-phenylethylamine

The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5′-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical production. To investigate the potential of vibra...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2026-01, Vol.130 (1), p.33-45
Main Authors: Dosanjh, Ramandeep S., Parker, Stewart F., Collier, Paul, Pushpanath, Ahir, York, Andrew P. E., Grainger, Damian, Tailor, Sanita B., Johnson, Timothy, Hyde, Timothy, Waddell, Lachlan J. N., Sutherland, Andrew, Lennon, David
Format: Article
Language:English
Subjects:
aldimines
B: Biophysical and Biochemical Systems and Processes
Density Functional Theory
Models, Molecular
neutrons
Phenethylamines - chemistry
physical chemistry
Propylamines - chemistry
pyridoxal
Pyridoxal Phosphate - analogs & derivatives
Pyridoxal Phosphate - chemistry
Raman spectroscopy
schiff bases
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
transamination
Vibration
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