Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis

Progressive multiple sclerosis (PMS) is an autoimmune demyelinating disease of the central nervous system (CNS) in humans. PMS is defined by neuroinflammation and axonal damage with advancing neurological disabilities, although the underlying molecular mechanisms remain uncertain. To gain insight in...

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Bibliographic Details
Published in:Nature communications 2026-01, Vol.17 (1), p.1368-16, Article 1368
Main Authors: Wang, Henry, Pollock, Niall M., Miranzadeh Mahabadi, Hajar, Patel, Jainilkumar, Moussa, Eman W., Fernandes, Jason P., Branton, William G., Zhang, Na, Elliott, Cameron, Schmitt, Laura, Power, Christopher, Julien, Olivier
Format: Article
Language:English
Subjects:
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Adult
Animal models
Animals
Astrocytes
Astrocytes - metabolism
Autoimmune diseases
Biomarkers
Brain
Brain - metabolism
Brain - pathology
Brain research
Cells (biology)
Central nervous system
Cuprizone
Damage
Demyelinating diseases
Demyelination
Disability
Disease control
Disease Models, Animal
Encephalitis
Encephalomyelitis, Autoimmune, Experimental - metabolism
Encephalomyelitis, Autoimmune, Experimental - pathology
Enrichment
Experimental allergic encephalomyelitis
Extracellular matrix
Extracellular Matrix Proteins - metabolism
Female
Genes
Glial cells
Glial stem cells
Humanities and Social Sciences
Humans
Lesions
Male
Mass spectrometry
Mass spectroscopy
Mice
Mice, Inbred C57BL
Microglia
Microglia - metabolism
Middle Aged
Molecular modelling
multidisciplinary
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - metabolism
Multiple Sclerosis, Chronic Progressive - pathology
Neural stem cells
Neurons
Neurons - metabolism
Ontology
Progenitor cells
Protein families
Proteins
Proteome - metabolism
Proteomes
Proteomics
Proteomics - methods
Science
Science (multidisciplinary)
Scientific imaging
Substantia alba
Therapeutic targets
Tissues
Toxins
White Matter - metabolism
White Matter - pathology
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