Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort

The accurate identification of individuals at risk of Alzheimer’s disease (AD) through blood-based biomarkers remains challenging. To evaluate the association between plasma amyloid-beta (Aβ)42/Aβ40 ratio and longitudinal amyloid deposition, clinical progression, brain atrophy and cognitive decline....

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Published in:Journal of Prevention of Alzheimer's Disease, The The, 2026, p.100465-100465, Article 100465
Main Authors: Fandos, Noelia, Pascual-Lucas, María, Sarasa, Leticia, Terencio, Jose, Sáez, Mª Eugenia, Tartari, Juan Pablo, Sanabria, Ángela, Sotolongo-Grau, Oscar, Cano, Amanda, Tárraga, Lluís, Gurruchaga, Miren Jone, Ruíz, Agustín, Montalban, Xavier, Boada, Mercè, Alegret, Montserrat, Marquié, Marta, Allué, José Antonio, Aguilera, N., Alarcón-Martín, E., Alegret, M., Alllué, J.A., Bayón-Bujan, P., Berthier, M., Blázquez-Folch, J., Boada, M., Buendia, M., Bullich, S., Campos, F., Calm-Salvans, B., Cano, A., Casales, F., Cañabate, P., Cañada, L., Cuevas, C., de Rojas, I., Diego, S., Domingues-Kolinger, G., Escudero, J.M., Espinosa, A., Fandos, N., Fernández, M.V., Gailhajenet, A., García-González, P., Giménez, J., Gómez-Chiari, M., Guitart, M., Gurruchaga, M.J., Gutiérrez, P.C., Hernández, I., Ibarria, M., Lafuente, A., Lomeña, F., Marquié, M., Martín, E., Martínez, C., Martinez, M., Miguel, A., Moreno, M., Morera, A., Montrreal, L., Muñoz, N., Muñoz-Morales, A., Niñerola, A., Nogales, A.B., Núñez, L., Olivé, C., Orellana, A., Ortega, G., Páez, A., Pancho, A., Pelejà, E., Pérez-Martínez, E., Pérez-Cordon, A., Pérez-Grijalba, V., Pascual-Lucas, M., Perissinotti, A., Preckler, S., Puerta, R., Ramis, M.I., Rodríguez, J.N., Roé-Vellvé, N., Romero, J., Rosende-Roca, M., Ruiz, A., Sanabria, A., Sanz-Cartagena, P., Sarasa, L., Seguer, S., Solivar, A., Sotolongo-Grau, O., Stephens, A., Tartari, J.P., Tárraga, L., Tejero, M.A., Terencio, J., Torres, M., Valenzuela, A., Valero, S., Vargas, L., Vivas, A.
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Aβ42/Aβ40
Blood biomarkers
Mass spectrometry
Neurology
Subjective cognitive decline
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