Identification of Some Interferences in the Analysis of Clorazepate

Clorazepate presents several problems in identification. In addition to rapid acid decarboxylation to N-desmethyldiazepam, a noncontrolled substance often confused with clorazepate, extracts of the pharmaceutical forms (Tranxene™ and Azenez™ capsules) contain substances that interfere with isolation...

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Bibliographic Details
Published in:Journal of forensic sciences 1983-07, Vol.28 (3), p.655-682
Main Authors: Suzuki, EM, Gresham, WR
Format: Article
Language:English
Subjects:
Anti-Anxiety Agents - analysis
Capsules - analysis
Clorazepate Dipotassium - analysis
Forensic Medicine
Nordazepam - analysis
Spectrophotometry, Infrared - methods
Time Factors
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Summary:Clorazepate presents several problems in identification. In addition to rapid acid decarboxylation to N-desmethyldiazepam, a noncontrolled substance often confused with clorazepate, extracts of the pharmaceutical forms (Tranxene™ and Azenez™ capsules) contain substances that interfere with isolation of intact and unaltered clorazepate. These substances have been identified and have been found to be quite dependent on both capsule type and, especially, on capsule age. The cause of the conversion of dipotassium clorazepate to the monopotassium salt, following solution, has also been identified. An infrared analysis method, which removes all of the interferences, is presented.
ISSN:0022-1198
1556-4029
DOI:10.1520/JFS11562J